Who discovered Proteus syndrome

The most famous case of what some suggest could be Proteus syndrome is that of Joseph Merrick, known as the Elephant Man. Merrick gained celebrity - and for a time earned his livelihood in England and Europe - by being displayed in human novelty exhibitions as the Elephant Man The syndrome is named after the Greek sea-god Proteus, who could change his shape. The condition appears to have been first described in the American medical literature by Samia Temtamy and John Rogers in 1976. Michael Cohen described it in 1979 Answer: Discovered by Voyager 2 spacecraft in 1989, it is named after Proteus, the shape-changing sea god of Greek mythology. Proteus circles Neptune in a nearly equatorial orbit at the distance of.. Proteus syndrome was first described by Cohen and Hayden (1979) and since then the highly variable clinical features of the syndrome have been redefined, in a consensus conference in 1998 (Biesecker et al., 1999). The unifying theme for Proteus syndrome is irregular, relentless, progressive overgrowth of multiple tissues

As follow up to the current study, NHGRI researchers plan to test DNA from the skeleton of Joseph Merrick to determine whether Proteus syndrome caused his dramatic disfigurement. Merrick gained celebrity — and for a time earned his livelihood in England and Europe — by being displayed in human novelty exhibitions as the Elephant Man Proteus syndrome is characterized by excessive growth of a part or portion of the body. The overgrowth is usually asymmetric, which means it affects the right and left sides of the body differently. Newborns with Proteus syndrome have few or no signs of the disorder. Overgrowth becomes apparent between the ages of 6 and 18 months and becomes more severe with age

When was Proteus syndrome discovered? What is the story of this discovery? Was it coincidence or not? Previous. 0 answers. Next. There are not any answers for this question yet. Become ambassador and add your answer History of Proteus syndrome Your answer What is the life expectancy of someone with Proteus syndrome?. What is Proteus Syndrome? Proteus syndrome is another form of disease that is rare and congenital in origin. The condition is also referred as Wiedemann's syndrome, coined after Hans-Rudolf Wiedemann. The condition is characterized by the overgrowth of skin and bone development Although the cause of Proteus syndrome is unknown to date, Happle [ 1987] first postulated that it might be caused by somatic mosaicism, lethal in the nonmosaic state (Fig. 1) Researchers at NIH have recently learned that Proteus syndrome is caused by a mosaic alteration, or mutation, in a gene called AKT1. The NIH research group, led by Dr. Leslie Biesecker, recently published their findings in a journal article in the New England Journal of Medicine

Proteus is a sporadic disorder resulting in a mosaic pattern of tissue overgrowth. The most common manifestations are macrodactyly, asymmetric fat and /or muscle and bone distribution, connective tissue and epidermal nevi, lymphatic and vascular malformations, and hyperostoses. Inheritance. Sporadic. Clinics Kim Green, the founder of the Proteus Syndrome Foundation, said DeVries is an important source of hope for children living with Proteus syndrome. He makes them not afraid because even though he..

Proteus syndrome (PS) was first described as a clinical entity by Cohen and Hayden [] in two patients in 1979.Dietrich et al. [] titled the disease, which has multiple, diverse, somatic manifestations, as the Greek god Proteus, who could change his form at will.PS is a complex hamartomatous disorder involving the skeletal system, skin, soft tissues, and vascular system An international team of researchers has reported in the New England Journal of Medicine the discovery of the gene that causes Proteus syndrome. The disease is a very rare developmental disorder. Proteus Syndrome was first described and categorized by Doctor Michael Cohen in 1979 and was named after the Greek god Proteus. This Greek god was capable of changing his shape. This name was chosen to reflect the gradual changes a person when through who was diagnosed with Proteus Syndrome

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  1. A: Proteus syndrome is likely caused by several different genes, with PTEN being only one of them. PTEN germline mutations likely cause up to 20 percent of cases of this syndrome. When an individual with Proteus syndrome is found to have a germline PTEN mutation, he or she has a 50 percent likelihood of passing on the PTEN mutation. Advertisement
  2. Proteus syndrome got its name from the Greek god Proteus, who would change his shape to elude capture. It's also thought that Joseph Merrick, the so-called Elephant Man, had Proteus syndrome...
  3. Proteus syndrome (PS) was described as a discrete clinical entity in 1979 1 and assigned its name several years later. 2 This is a relatively recently delineated syndrome, probably because it is.
  4. Proteus syndrome Clinical features. Proteus syndrome was first described by Cohen and Hayden (1979) and since then the highly variable clinical features of the syndrome have been redefined, in a consensus conference in 1998 (Biesecker et al., 1999). The unifying theme for Proteus syndrome is irregular, relentless, progressive overgrowth of.
  5. The neuromas of NF1 were first detailed by Smith in 1849, but Frederick von Recklinghausen is credited with its discovery and coined the name of the disorder in 1882. NF1 research widely increased between 1909 and 1990, due to the erroneous diagnosis of the Elephant Man, Joseph Merrick
  6. Proteus syndrome is a rare condition characterized by overgrowth of the bones, skin, and other tissues. Organs and tissues affected by the disease grow out of proportion to the rest of the body. The overgrowth is usually asymmetric, which means it affects the right and left sides of the body differently
  7. In cases of Proteus syndrome - only a few hundred have been reported in the world - organs and tissues grow out of proportion to the rest of the body. The overgrowth is usually asymmetric and can be disfiguring, as in the case of Joseph Merrick, a 19th-century Englishman who became known as the Elephant Man

What is it? Proteus syndrome is a rare disease characterized by significant growth of bones, skin and other tissues. The organs and tissues affected by this pathology are disproportionately large in relation to the rest of the body. This abnormal size of certain organs and / or tissues is generally asymmetrical. Indeed, the disease can affect the [ NF-1 was formerly known as von Recklinghausen disease, after the researcher (Friedrich Daniel von Recklinghausen) who first documented the disorder. The severity of NF-1 varies widely, and little is known about what causes a person to have a more severe or less severe case

Tumors of genitourinary tract in Proteus syndrome are uncommon. CASE: We here report a 5-year-old girl with Proteus syndrome who developed a cystic mass in the pelvic cavity. The cyst was discovered by ultrasonographic examination and finally proved to be a unilateral ovarian dermoid cyst accompanied by an ipsilateral paratubal cyst by. Proteus syndrome is an overgrowth disorder caused by a rare genetic mosaicism. It was discovered by Drs. Samia Temtamy and John Rogers. There are three general characteristics of features that must be present for doctors to consider a diagnosis of Proteus Syndrome: Mosaic distribution, sporadic occurrence, an BURLINGTON, Mass.--(BUSINESS WIRE)--ArQule, Inc. (Nasdaq: ARQL) today announced that the FDA has granted Rare Pediatric Disease Designation to miransertib (ARQ 092) for the treatment of Proteus syndrome.Under the FDA's rare pediatric disease priority review voucher program, the sponsor may be eligible for a voucher that can be used to obtain priority review for a subsequent human drug. Proteus syndrome is a rare genetic disorder distinguished by an overgrowth of many different tissues in the body in a mosaic pattern. The skin, the musculoskeletal system, the central nervous system, and adipose tissues are affected the most, producing profound disfigurement and life-threatening complications. The diagnosis is made through a combination of clinical criteria and positive. Proteus Syndrome. Hans-Rudolph Wiedemann is the pediatrician that discovered Wiedemann syndrome, later called Proteus Syndrome. The congenital disorder causes the skin to continue growing, bone to continue developing and tumors to grow on more than half the body. The result is several deformation of the face, hands, feet, trunk and other parts.

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  1. The most likely contender is a recently-discovered genetic condition called proteus syndrome. Advertisement Joseph Merrick was born in 1862, and lived only twenty-seven years, most of them filled.
  2. To confirm the link to Proteus syndrome, the scientists searched for the mutation in additional patients with the disorder. The suspect variant was found in 26 of the 29 people tested. By contrast, the variant was never found in unaffected people, including thousands of DNA sequences maintained in public genome research databases
  3. In 1983 a German pediatrician named the syndrome after the Greek god Proteus. This is a patient we reported in the Archives of Dermatology (Samlaska CP, et al. Proteus Syndrome. Arch Dermatol 1989;125:1109-1114). We now know that the cause is related to a mosaic gene mutation in AKT1, which was discovered in 2011
  4. Background: Proteus syndrome (PS) is an extremely rare disease characterized by excessive chimeric growth of cells, and progressive and irregular asymmetrical hyperplasia. Case presentation: Herein, a PS case with atypical clinical features and syndromes was reported, to improve the understanding of the diagnosis and treatment of the disease
  5. American researchers have identified a genetic mutation that causes Proteus syndrome, a rare disorder in which tissue and bone grow massively out of proportion. About 500 people are known to to be.

Proteus Syndrome - Background - Genome

  1. ation, including X-rays and possibly other imaging tests, such as computerized tomography (CT), magnetic resonance imaging.
  2. Proteus species are part of the Enterobacteriaceae family of gram-negative bacilli. The first isolates were reported and characterized by Hauser in the late 19th century. The genus is currently composed of Proteus mirabilis, Proteus vulgaris, Proteus penneri, Proteus hauseri, Proteus terrae, and Proteus cibarius.P mirabilis and P vulgaris account for most clinical Proteus isolates
  3. Proteus syndrome is a medical condition that leads to disproportionate growth of tissues such as bone, skin, vascular and fatty tissue. This page from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of Proteus syndrome and where to get help. A syndrome is a collection of signs and symptoms that have the same cause

Proteus syndrome - Wikipedi

The Proteus Syndrome pipeline report provides detailed information of the Proteus Syndrome pipeline products from the initial phase of product development until its commercialisation in the Proteus Syndrome market The Proteus syndrome: partial gigantism of the hands and/or feet, nevi, hemihypertrophy, subcutaneous tumors, macrocephaly or other skull anomalies and possible accelerated growth and visceral affections Europ J Pediat. 1983;140: 5-12, Lindhurst JM, et al. A mosaic activating mutation in AKT1 associated with the Proteus syndrome Proteus Syndrome Have you ever heard of Joseph Merrick, more commonly known as the Elephant Man? Merrick is probably the most interesting example of all skin-anomalies. The correct diagnosis for Merrick's condition was not discovered until 1979,

The disorder from which Merrick suffered was long thought to be an extremely severe case of neurofibromatosis, but his deformities were probably the result of an extremely rare disease known as Proteus syndrome. Merrick was confined to a workhouse at age 17, then escaped four years later to join a freak show (1883). While on exhibition, he was. Proteus syndrome is an uncommon and complex disorder characterized by variable clinical findings of overgrowth and tumor susceptibility. It was first described by Cohen and Hayden in 1979 4 and later termed Proteus syndrome by Wiedemann et al in 1983 5 due to its phenotypic heterogeneity Proteus syndrome Background. Proteus syndrome is a rare disorder named after the Greek god Proteus, 'the polymorphous', who could change shape at will to avoid capture. The name reflects the highly variable presentation of this disorder. Wiedemann and colleagues in 1983 who named it were unaware that this syndrome had already been described What Is Proteus Syndrome And Who Gets Proteus Syndrome? • Proteus syndrome is very rare. Only a few hundred people are thought to be afected with this condition worldwide. Because it is so rare, it can be difcult for doctors to accurately diagnose Proteus syndrome Proteus syndrome is a rare condition characterized by overgrowth of the bones, skin, and other tissues

Who discovered proteus syndrome? - Answer

Proteus Syndrome This extremely rare condition may be confused with Maffucci syndrome. It is characterized by cerebriform connective tissue nevi (moccasin feet), epidermal nevi, lipomas and disproportionate, relentless, and asymmetrical skeletal overgrowth. Patients with Proteus are essentially normal at birth, except for the nevi The general prevalence of Proteus syndrome is less than 1 case per 1,000,000 live births. Perhaps the most famous patient with Proteus syndrome is, so called, Elephant Man. The elephant man was Joseph Carey Merrick, a citizen of London, who became a true sensation back in the late 19th century. Symptoms of Proteus syndrome Proteus Syndrome (PS) is an extremely rare congenital pathology that causes overgrowth of multiple tissues, in particular AKT1, was discovered in 2011, confirming the genetic nature of the syndrome. The estimated incidence is of less than 1 per 1,000,000 live births, with a male/female.

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Proteus Syndrome - an overview ScienceDirect Topic

A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome. New England Journal of Medicine , 2011; 110727140030013 DOI: 10.1056/NEJMoa1104017 John M. Opitz, Lynn B. Jorde Plural Of Weather, Anomaly Defenders, Sleeveless Zip Up Hoodie Men's, Women's Leather Flip Flops With Arch Support, Wits Junior Football Club Contact Details, 49ers 2019 Preseason Schedule, How To Clean Suede Bag Lining, Northgard Stats, Raid: Shadow Legends Email, List Of Appalachian Foods, BNP Paribas Fortis English, Oldest Person With Proteus Syndrome, How To Pronounce Juncture, Who. Positive information about pre-clinical, and early stage clinical trial results, including in Proteus syndrome, does not ensure that later stage or larger scale clinical trials will be successful

Did Joseph Merrick, known as "elephant man," have ProteusProteus Syndrome with Arteriovenous Malformation Asilian AGiant Head Disease Turns Man Into Monster | Odd/Strange

The NHGRI inventors have generated cell lines from patients with Proteus syndrome and discovered that a somatic activating mutation in the serine-threonine kinase AKT1 is associated with Proteus syndrome. AKT1 is an oncogene and an enzyme known to mediate cell proliferation and apoptosis (programmed cell death process) and has been a target for. Greek mythology . Proteus was first discovered by Gustav Hauser [Figure 1], a German pathologist, in 1885.[] Accounting for more than 90% of proteus infections, Proteus mirabilis is a highly motile Gram-negative bacterium.[] The ability of Proteus mirabilis to differentiate from short vegetative swimmer cells to an elongated, highly flagellated swarmer form is a distinctive feature of this.

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Cowden syndrome was estimated to affect 1 in 200,000 individuals; this study was conducted just as PTEN was discovered. However, because the disorder is difficult to recognize, researchers believe it is under-diagnosed, making it difficult to determine its true frequency in the general population Proteus syndrome is a rare condition categorized as a hamartomatous disorder with multisystem involvement and great clinical variability. (Once thought to have neurofibromatosis, Joseph Merrick, of fame since he was known asThe Elephant Man, is. A Case of Proteus Syndrome with Hemangioma Presentation PS is a rare disease with a worldwide prevalence of less than one in every one million people [2]. Due to the rarity and high variability, there are no sensitive and specific diagnostic criteria. Misdiagnosis of PS had been common before the diagnostic criteria were introduced in 1999, and. The Proteus Syndrome report provides an overview of therapeutic pipeline activity and therapeutic assessment of the products by development stage, product type, route of administration, molecule. Discussion Other manifestations of Proteus syndrome, such Proteus syndrome is a very rare condition, first described by as a right hypertrophy of the face with hypoplasia of its Cohen [11], and mostly diagnosed during the first decade of middle third, a pigmented epidermal nevus and asymmetric life

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Follow-up examination showed development of hemihypertrophy and other findings suggesting Proteus syndrome (176920). Molecular Genetics In 6 patients with macrodactyly, Rios et al. (2013) identified 4 different somatic mutations (e.g., 171834.0022) in the PIK3CA gene in affected tissue The cyst was discovered by ultrasonographic examination and finally proved to be a unilateral ovarian dermoid cyst accompanied by an ipsilateral paratubal cyst by laparoscopic surgery. Summary and conclusion Proteus syndrome accompanied by an ovarian cyst is rare in girls An examination of the life and remains of Joseph Merrick aka The Elephant Man, a Victorian age man who was deformed with a severe case of Proteus Syndrome. Director: Mark Radice | Star: Richard Lintern. Votes: 1 Symptoms can appear at any age, including infancy. In more than half of EV cases, symptoms first appear in children between the ages of 5 and 11. For nearly a quarter of people with EV, symptoms.

NIH researchers identify gene variant in Proteus syndrome

Urease producing bacteria. (proteus, klebsiella, pseudomonas, enterobacter) ____ can detect renal parenchyma disease based on increased echogenicity of renal parenchyma as compared to the liver. US. Xanthogranulomatous pyelonephritis is a replacement of parenchyma by _____ macrophages and is associated with obstructing stone disease. Foamy Saethre-Chotzen syndrome (SCS), also known as acrocephalosyndactyly type III, is a rare congenital disorder associated with craniosynostosis (premature closure of one or more of the sutures between the bones of the skull).This affects the shape of the head and face, resulting in a cone-shaped head and an asymmetrical face. Individuals with SCS also have droopy eyelids (ptosis), widely spaced. Waking up with shoulder pain is not the way you want to start your day. If morning shoulder pain is a daily occurrence, it could signal a treatable condition that can become worse if ignored. Learn some common causes of shoulder pain when waking up, and how you can find relief

Proteus syndrome Genetic and Rare Diseases Information

EDEXCEL A LEVEL. Ed Lees Martin Rowland C. J. Clegg. DYNAM I C, , HODDER.-c::a L EARNING EDUCATION AN HACHETTE UK COMPANY A.khough every effort has been n1ade to ensure that ·website addresses are correct at tin1e of going to press, Hodder Education cannot be held responsible for the content of :my website mentioned in this book. It is sometin1es possible to find a relocated ,velb page by. The DogData ecosystem facilitates solutions solving Dog welfare problems using modern technologie • The term Proteus syndrome was coined in 1983 to describe a disorder of skeletal, hamartomatous, and other mesodermal malformations. The syndrome was named after the Greek god Proteus, whose name means the Polymorphous. Clinical features of this new syndrome are currently being defined. Including.. Proteus syndrome- a rare condition where overgrowth of the bones, skin, and other tissues occurs. Organs and tissues affected by the disease grow out of proportion to the rest of the body, a kind of uncontrolled growth. The overgrowth is usually not uniform and is asymmetric, which means it affects the right and left sides of the body differently

Proteus Syndrome was first described by Cohen and Hayden in 1979, but actually Wiedemann was who called to this disease as Proteus Syndrome in 1983. The syndrome was named in this way beacuse of the Greek god Proteus (the polymorphous), who could get such a lot of forms according to the legends In the late 1970s doctors began to theorize that a disease known as Proteus syndrome could be the cause of the Elephant Man's condition. Proteus syndrome is a rare condition caused by a mutated gene called PTEN. So researchers in England enlisted the help of Dr. Charis Eng, Director of the Division of Human Genetics at Ohio State University 10: Proteus Syndrome. Joseph Merrick, the Elephant Man, poses for a photo. Although Joseph Merrick's career in sideshows was rather short-lived, he became well-known by posterity for his affliction (he was known as the Elephant Man ) and the sweet nature that allowed him to befriend Queen Victoria Background Proteus syndrome is a rare congenital disorder with progressive asymetric overgrowth of multiple tissues.. Objectives To determine the range of cutaneous findings in Proteus syndrome and to correlate cutaneous findings with overall disease severity.. Design A prospective cohort study was performed at the National Institutes of Health, a tertiary referral center

What is the history of Proteus syndrome

There have been tests carried out on one person, a team of scientists tested Rapamycin on a patient presumably suffering from Proteus Syndrome, and they discovered it to be effective, but the patient's diagnosis of the Elephant Man Disease has been highly contested by others Proteus syndrome and PROS are rare mosaic disorders. Early on in utero , a small islet of cells acquires an unusual mutation, such as AKT1 or PI3K , which mature as the embryo grows. After birth, these children often appear normal; however, as they continue to develop these little islets grow at a much higher rate than the rest of the body The proteus syndrome can vary from individual to individual, and it is said to occur in less than one in one million people. And in fact, only a few hundred documented cases have ever been reported. This disorder results from a mutation in the AKT1 gene (which regulates cell growth), causing mosaicism, as cells grow and divide, some cells.

Proteus Syndrome - Pictures, Symptoms, Causes, Treatment

Proteus, in Greek mythology, the prophetic old man of the sea and shepherd of the sea's flocks (e.g., seals). He was subject to the sea god Poseidon, and his dwelling place was either the island of Pharos, near the mouth of the Nile River, or the island of Carpathus, between Crete and Rhodes. Britannica Quiz. Gods, Goddesses, and Greek Mythology Proteus syndrome (PS) is a rare medical condition that was first described in 1979 by Cohen and Hyden, and it was named Proteus after a Greek god, who was able to transform his body into multiple shapes.1 Proteus syndrome is characterized by overgrowth of many tissues that can be localized in a particular body segment or involve many areas. The affected tissues are derived from all 3 germ layers Proteus syndrome is a rare, sporadic disorder that causes postnatal overgrowth of multiple tissues in a mosaic pattern. A second patient had bilateral ovarian cysts of unknown size discovered. Proteus syndrome is a very rare condition, first described by Cohen [], and mostly diagnosed during the first decade of life.It is thought that Joseph Merrick also known as the Elephant Man, who lived in the late nineteenth century, had the Proteus syndrome [].It is characterised by progressive, segmental overgrowth of various tissues, most commonly affecting the skin, skeleton, adipose. Born with a rare condition, Mandy Sellars' petite 84-pound frame is supported by abnormally large legs that weigh 210 pounds. Her doctors, who are still baffled by her disorder, have tentatively diagnosed her with a form of Proteus syndrome (made famous by The Elephant Man) for lack of a more definitive explanation

MICROBIOLOGY. Proteus is a member of the Enterobacteriaceae family. The genus of Proteus consists of motile, aerobic and facultatively anaerobic, Gram-negative rods.Proteus is a member of the tribe Proteeae, which also includes Morganella and Providencia.The genus Proteus currently consists of five named species: P. mirabilis, P. vulgaris, P. penneri, P. myxofaciens and P. hauseri and three. In Proteus syndrome the mutation (changed gene) occurs after conception, leaving some fetal cells with defective cell growth and others as normal, a so-called mosaic pattern. Fewer than 500 people in the developed world are known to suffer from Proteus syndrome, and it took nearly five years to gather the data from patients phantiasis. However, in July 2003, doctors discovered and announced that Merrick actually suffered from Proteus syndrome. Named after the Greek god who could change his shape, Proteus syndrome is a rare disorder of the lymphatic system which causes overgrowth of one side of the body, an abnormally large head, and darkened spots or moles on the.

Proteus Syndrome. The medical name for Human Elephant Disease is Proteus Syndrome. Michael Cohen, Jr., DMD, Ph.D discovered it in 1979, but medical references to a similar condition exist as far back as 1907. Symptoms. Proteus Syndrome causes large tumors to grow above and below the skin. Asymmetric overgrowth of the body is another characteristic Greek mythology Proteus was first discovered by Gustav Hauser , a German pathologist, in 1885. Accounting for more than 90% of proteus infections, Proteus mirabilis is a highly motile Gram-negative bacterium. The ability of Proteus mirabilis to differentiate from short vegetative swimmer cells to an elongated, highly flagellated swarmer form is a distinctive feature of this organism. The Proteus Syndrome can only be diagnosed by genetic testing. The condition derives its name from the Greek god of change Proteus, because the patient's body is constantly changing due to. Hamartomatous Polyposis Syndromes (HPS) are genetic syndromes, which include Peutz-Jeghers syndrome, Juvenile polyposis syndrome, PTEN hamartoma tumour syndrome (Cowden Syndrom, Bannayan-Riley-Ruvalcaba and Proteus Syndrome) as well as hereditary mixed polyposis syndrome. Other syndromes such as Gorlin Syndrome and multiple endocrine neoplasia syndrome 2B are sometimes referred to as HPS

Proteus syndrome: An update - Cohen - 2005 - American

The gene that gave Proteus syndrome to 16-year-old Jordan (wearing prosthetic legs) may also explain the Elephant Man's deformities. Soil without detectable life discovered in Antarctica. By. Proteus syndrome is an extremely rare disorder, making tissue sample collection especially challenging, said Laura L. Tosi, MD, of the Division of Orthopaedic Surgery and Sports Medicine at Children's National. Given the importance of this research, we stepped up to the plate and, over the last decade, Children's National surgeons. More than 50 affected individuals with Proteus syndrome have now been reported in the literature, Wiedemann and colleagues (1,2) were the first to recognize the condition as a distinct entity, although several previous papers were subsequently discovered describing the same disorder (3-5), The earliest known reference was in 1928 (6), The. The Proteus Syndrome - Pipeline Insight, 2020 drug pipelines has been added to ResearchAndMarkets.com's offering

Genetic Disorders to Present Internet resources to help in research Rubric for project You have been challenged to incorporate your knowledge about cells, cell division, genetics, and DNA to research and present on a specific genetic disorder. You have already completed your basic study about the ideas of genetics and mutations. Now with the Continue reading Genetic Disorder Project. A team of researchers has identified the genetic mutation that causes Proteus syndrome, a rare disorder in which tissue and bone grows massively out of proportion Proteus Syndrome Overview And Case Study Analysis Proteus syndrome is an appreciably amazing extra ailment idea to influence much less than 500 human beings in the created world. It is portrayed by the dynamic and irregular improvement of physique tissues, inclusive of skin, bones, greasy tissues and veins. In 1979, Canadian-base The Watson Case: An Impossible Surgery Makes a Night-and-Day Difference for a Patient with Proteus Syndrome. By the time 39-year-old Ricky Watson saw Amber U. Luong, MD, PhD, he could no longer swallow, eat or talk.His only avenue of communication with his family was writing on a notepad or texting via cell phone